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ALISKIREN PLASMA CONCENTRATION IS REDUCED UP TO 50%
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INCREASED HYPOTENSIVE EFFECT IS SEEN
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CONCURRENT USE MAY ENHANCE THE POTENTIAL FOR DRUG-INDUCED RENAL TOXICITY IN PATIENTS WHOSE RENAL FUNCTION DEPENDS UPON ACTIVITY OF RENIN-ANGIOTENSIN-ALDOSTERON SYSTEM EG. PATIENTS WITH SEVERE CHF
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